"...knock and the door will be opened to you." Matthew 7:7
I typically start on the upper lefthand corner, adding one quilt square to the right or below my first block. Sometimes I'll break up the blockiness by incorporating a circle.
I used a simple stencil to add the circle, colored it in and added a "k" sticker" as a title.
Here's another example...you can go BIG on your title letters and use the space to add verses: